Article
The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.
Molecular pharmacology - 1 Feb 1994
Jensen C J, Gerard N P, Schwartz T W, Gether U
Abstract excerpt
During evolution mutations have occurred in peptide receptors that are neutral with respect to binding of the natural peptide ligand but frequently affect the binding of nonpeptide antagonists. By systematically introducing the nonconserved residues from the human neurokinin (NK)-1 receptor into...
Topics
- Amino Acid Sequence
- Animals
- Benzamides
- Biphenyl Compounds
- Cell Line
- Dipeptides
- Humans
- Indoles
- Molecular Sequence Data
- Mutation
- Neurokinin-1 Receptor Antagonists
- Piperidines