Article
Interaction of biphenylimidazole and imidazoleacrylic acid nonpeptide antagonists with valine 108 in TM III of the AT1 angiotensin receptor.
British journal of pharmacology - 1 Dec 1996
Nirula V, Zheng W, Sothinathan R, Sandberg K
Abstract excerpt
Interspecies amino acid exchange, based on pharmacological differences between mammalian AT1 and amphibian xAT angiotensin II receptors, previously demonstrated that Val108 in transmembrane III (ValIII:08) is a critical structural requirement for binding the biphenylimidazole, losartan. Here, we...
Topics
- Angiotensin I
- Angiotensin Receptor Antagonists
- Animals
- Biphenyl Compounds
- COS Cells
- Imidazoles
- Ligands
- Mutation
- Receptors, Angiotensin
- Valine