Article
The C-terminus of the homeodomain is required for functional specificity of the Drosophila rough gene.
Mechanisms of development - 1 Oct 1994
Heberlein U, Penton A, Falsafi S, Hackett D, Rubin G M
Abstract excerpt
In contrast to most Drosophila homeobox genes, which are required during embryogenesis, the rough gene is involved in photoreceptor cell specification in the compound eye. Taking advantage of the viability of null rough alleles and the small size of the rough gene, we have combined in vivo and in vitro mutagenesis to define important functional domains in the rough protein. All missense mutations found to disrupt...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Cycle Proteins
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Microtubule-Associated Proteins
- Molecular Sequence Data
- Mutagenesis