Structural and functional comparisons of the Drosophila virilis and Drosophila melanogaster rough genes.

doi:10.1073/pnas.87.15.5916

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Article

Structural and functional comparisons of the Drosophila virilis and Drosophila melanogaster rough genes.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Heberlein U, Rubin G M

Abstract excerpt

We have isolated the homeobox gene rough (ro) from Drosophila virilis. Comparison of the predicted amino acid sequences of the D. melanogaster and D. virilis rough proteins reveals that domains of high conservation, including the homeodomain, are interspersed with highly diverged regions. Stretches of significant sequence conservation are also observed in the 5' promoter region and in the introns. The D. virilis...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Cell Cycle Proteins
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Drosophila melanogaster
Genes, Homeobox
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomic Library

Introns

Microtubule-Associated Proteins

Molecular Sequence Data

Promoter Regions, Genetic

Sequence Homology, Nucleic Acid

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 1974051
DOI: 10.1073/pnas.87.15.5916
PMCID: PMC54440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1974051-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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