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Article

Rough genes with Deformed homeobox substitutions exhibit rough regulatory specificity during Drosophila eye development.

Mechanisms of development - 1 Apr 1993

Lockett T J, Moretti P A, Lake J A, Saint R

Abstract excerpt

In certain cases, homeobox genes with different in vivo roles encode proteins with similar in vitro DNA binding specificities. To test the role of the homeobox in the regulatory specificity of such genes, rough homeobox sequences were changed in part or entirely to those of the Deformed gene, and the modified rough genes tested for their ability to rescue the rough mutant phenotype. Surprisingly, the chimaeric...

Topics

Amino Acid Sequence
Animals
Base Sequence
Drosophila melanogaster
Eye
Genes, Homeobox
Genes, Regulator
Molecular Sequence Data
Phenotype
Sequence Homology, Amino Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8099496
DOI: 10.1016/0925-4773(93)90055-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8099496-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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