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Article

Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough.

Genes & development - 1 May 1990

Basler K, Yen D, Tomlinson A, Hafen E

Abstract excerpt

In the developing eye of Drosophila, the homeo box gene rough is required in the developing photoreceptor cells R2 and R5 for the correct development of the neighboring R3 and R4 cells. We have expressed rough ectopically in a limited subset of developing ommatidial cells using the sevenless enha...

Topics

Animals
Base Sequence
Cell Differentiation
Drosophila
Enhancer Elements, Genetic
Gene Expression Regulation
Genes
Genes, Homeobox
Genes, Lethal
Genotype
Molecular Sequence Data
Mosaicism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Photoreceptor Cells

Retina

Source

Identifiers

PMID: 1974229
DOI: 10.1101/gad.4.5.728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1974229-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough.PMID 1974229Read ↗

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The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype.Semantic proximity Read ↗

Cell-fate determination in the developing Drosophila eye: role of the rough gene.Semantic proximity Read ↗

senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye.Semantic proximity Read ↗

Identifying targets of the rough homeobox gene of Drosophila: evidence that rhomboid functions in eye development.Semantic proximity Read ↗

rhomboid mediates specification of blue- and green-sensitive R8 photoreceptor cells in Drosophila.Semantic proximity Read ↗

Ectopic expression of seven-up causes cell fate changes during ommatidial assembly.Semantic proximity Read ↗

pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.Semantic proximity Read ↗

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Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate.Semantic proximity Read ↗

Star is required in a subset of photoreceptor cells in the developing Drosophila retina and displays dosage sensitive interactions with rough.Semantic proximity Read ↗

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