Article
The contribution of endogenous sources of DNA damage to the multiple mutations in cancer.
Mutation research - 2 Jun 2001
Jackson A L, Loeb L A
Abstract excerpt
There is increasing evidence that most human cancers contain multiple mutations. By the time a tumor is clinically detectable it may have accumulated tens of thousands of mutations. In normal cells, mutations are rare events occurring at a rate of 10(-10) mutations per nucleotide per cell per generation. We have argued that the mutation rates exhibited by normal human cells are insufficient to account for the...
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