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Article

Endogenous DNA damage and mutation.

Trends in genetics : TIG - 1 Apr 2001

Marnett L J, Plastaras J P

Abstract excerpt

In humans, approximately 10(7) cells divide per second. Estimates suggest that spontaneous mutations arise in about a third of those cells. These mutations arise as mistakes in DNA replication and when DNA polymerases copy damaged templates. The latter result from chemical hydrolysis of nucleoside bases or by reaction of DNA with electrophiles or reactive free radicals generated during metabolism (endogenous DNA...

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Identifiers

PMID: 11275327
DOI: 10.1016/s0168-9525(01)02239-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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