Article
Potential sources of multiple mutations in human cancers.
Preventive medicine - 1 Jul 1995
Christians F C, Newcomb T G, Loeb L A
Abstract excerpt
Increasing evidence indicates that most human cancers contain multiple chromosomal alterations. These aberrations are the result of mutations produced not only during the initiation of cancer but also during tumor progression. Since the rates of spontaneous mutations exhibited by normal human cells cannot account for the large numbers of mutations routinely reported in human cancers, we argued that cancer cells...
Topics
- Chromosome Aberrations
- DNA Replication
- DNA, Neoplasm
- Disease Progression
- Humans
- Mutagenesis
- Mutation
- Neoplasms
- Proto-Oncogenes