Article
An overview of the mechanisms of mutagenesis and carcinogenesis.
Mutation research - 1 Nov 2003
Sarasin Alain
Abstract excerpt
Cancer is a genetic disease due to the accumulation of numerous mutations rendering the tumour cell insensitive to control by the local cellular environment and by the whole organism. Analysis of the frequency of appearance of human cancer as a function of age shows that between four and seven mutations in key genes are usually necessary to produce most human cancers. Interesting debates in the literature are...
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