Article
Effects of Escherichia coli dnaE antimutator alleles in a proofreading-deficient mutD5 strain.
Journal of bacteriology - 1 Oct 1995
Fijalkowska I J, Schaaper R M
Abstract excerpt
We have previously isolated seven mutants of Escherichia coli which replicate their DNA with increased fidelity. These mutants were isolated as suppressors of the elevated mutability of a mismatch-repair-defective mutL strain. Each mutant was shown to contain a single amino acid substitution in the dnaE gene product, the alpha (i.e., polymerase) subunit of DNA polymerase III holoenzyme responsible for replicating...
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