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Article

Autosomal dominant familial spastic paraplegia: tight linkage to chromosome 15q.

American journal of human genetics - 1 Jan 1995

Fink J K, Wu C T, Jones S M, Sharp G B, Lange B M, Lesicki A, Reinglass T, Varvil T, Otterud B, Leppert M

Abstract excerpt

Autosomal dominant, uncomplicated familial spastic paraplegia (FSP) is a genetically heterogeneous disorder characterized by insidiously progressive lower-extremity spasticity. Recently, a locus on chromosome 14q was shown to be tightly linked with the disorder in one of three families. We perfor...

Topics

Adolescent
Adult
Axons
Centromere
Child
Chromosomes, Human, Pair 15
Female
Genes, Dominant
Genotype
Humans
Ireland
Lod Score
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Degeneration

Pedigree

Spastic Paraplegia, Hereditary

United States

Source

Open in PubMed Open full text

Identifiers

PMID: 7825577
PMCID: PMC1801321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7825577-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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