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Article

Autosomal dominant familial spastic paraplegia: tight linkage to chromosome 15q.

American journal of human genetics - 1 Jan 1995

Fink J K, Wu C T, Jones S M, Sharp G B, Lange B M, Lesicki A, Reinglass T, Varvil T, Otterud B, Leppert M

Abstract excerpt

Autosomal dominant, uncomplicated familial spastic paraplegia (FSP) is a genetically heterogeneous disorder characterized by insidiously progressive lower-extremity spasticity. Recently, a locus on chromosome 14q was shown to be tightly linked with the disorder in one of three families. We performed linkage analysis in a kindred with autosomal dominant uncomplicated FSP. After excluding the chromosome 14q locus,...

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PMID: 7825577
PMCID: PMC1801321

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