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Article

Linkage of a new locus for autosomal dominant familial spastic paraplegia to chromosome 2p

1 Jan 1994

Abstract excerpt

Autosomal dominant familial spastic paraplegia (AD-FSP) is a genetically heterogeneous neurodegenerative disorder characterized by a spasticity of the lower limbs. A locus causing AD-FSP (FSP1) has been previously mapped to chromosome 14q. We now report linkage of a second AD-FSP locus (FSP2) to chromosome 2p21-p24 in five of seven French families and one large Dutch pedigree. The analysis of recombination events...

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Identifiers

PMID: 7833913
DOI: 10.1093/hmg/3.9.1569

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