Extensive genetic heterogeneity in the "pure" form of autosomal dominant familial spastic paraplegia (Strümpell's disease).

doi:10.1002/(SICI)1097-4598(199611)19:11<1435::AID-MUS8>3.0.CO;2-D

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Article

Extensive genetic heterogeneity in the "pure" form of autosomal dominant familial spastic paraplegia (Strümpell's disease).

Muscle & nerve - 1 Nov 1996

Kobayashi H, Garcia C A, Tay P N, Hoffman E P

Abstract excerpt

Three dominantly inherited "pure" form of familial spastic paraplegia (FSP) genes have been genetically mapped to regions of chromosomes, yet no specific genes or mutations have been identified (FSP1; chromosome 14q, FSP2; chromosome 2p and FSP3; chromosome 15q). We studied a "pure" form of autos...

Topics

Chromosome Mapping
Genes, Dominant
Genetic Linkage
Genetic Markers
Genetic Variation
Humans
Male
Middle Aged
Pedigree
Spastic Paraplegia, Hereditary

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