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Clinical and genetic studies in hereditary spastic paraplegia with thin corpus callosum

27 Jan 2004

Abstract excerpt

BACKGROUND: A complicated form of recessive hereditary spastic paraplegias (HSPs) with thin corpus callosum (TCC) was first described in Japan, and most of the Japanese families showed linkage to chromosome 15q13-15. A recessive HSP locus (SPG11) has also been mapped to chromosome 15q13-15 in Italian and North American families with and without TCC, and it overlaps the region identified in the Japanese families....

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PMID: 14745065
DOI: 10.1212/wnl.62.2.262

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