Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q.

Neurology - 8 May 2001

Hughes C A, Byrne P C, Webb S, McMonagle P, Patterson V, Hutchinson M, Parfrey N A

Abstract excerpt

The authors studied two families with autosomal recessive hereditary spastic paraplegia (HSP) complicated by the presence of additional symptoms of pigmented maculopathy, distal amyotrophy, dysarthria, mental retardation, and further intellectual deterioration. Evidence was obtained for linkage to a locus on chromosome 14q that is distinct from the SPG3 locus for autosomal dominant HSP (D14S77: lod score of 4.20...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 14
Share to Genetic Linkage
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Pedigree

Share to Spastic Paraplegia, Hereditary

Source

Identifiers

PMID: 11342696
DOI: 10.1212/wnl.56.9.1230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q.PMID 11342696Read ↗

Refinement of the SPG15 candidate interval and phenotypic heterogeneity in three large Arab families.Semantic proximity Read ↗

The Silver syndrome variant of hereditary spastic paraplegia maps to chromosome 11q12-q14, with evidence for genetic heterogeneity within this subtype.Semantic proximity Read ↗

A new locus for autosomal dominant "pure" hereditary spastic paraplegia mapping to chromosome 12q13, and evidence for further genetic heterogeneity.Semantic proximity Read ↗

Autosomal dominant spastic paraplegia: refined SPG8 locus and additional genetic heterogeneity.Semantic proximity Read ↗

A new phenotype linked to SPG27 and refinement of the critical region on chromosome.Semantic proximity Read ↗

Clinical and genetic study of a large Italian family linked to SPG12 locus.Semantic proximity Read ↗

Spastic paraplegia 5: Locus refinement, candidate gene analysis and clinical description.Semantic proximity Read ↗

A new locus for autosomal recessive spastic paraplegia (SPG32) on chromosome 14q12-q21.Semantic proximity Read ↗

Autosomal dominant spastic paraplegia with peripheral neuropathy maps to chr12q23-24.Semantic proximity Read ↗

A novel locus for an autosomal recessive hereditary spastic paraplegia (SPG35) maps to 16q21-q23.Semantic proximity Read ↗

Spastic paraplegia with thin corpus callosum: description of 20 new families, refinement of the SPG11 locus, candidate gene analysis and evidence of genetic heterogeneity.Semantic proximity Read ↗

A clinical and genetic study of SPG5A linked autosomal recessive hereditary spastic paraplegia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.