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Article

Fine mapping and genetic heterogeneity in the pure form of autosomal dominant familial spastic paraplegia.

Neurogenetics - 1 Mar 2001

Ashley-Koch A, Bonner E R, Gaskell P C, West S G, Tim R, Wolpert C M, Jones R, Farrell C D, Nance M, Svenson I K, Marchuk D A, Boustany R M, Vance J M, Scott W K, Pericak-Vance M A

Abstract excerpt

We evaluated seven families segregating pure, autosomal dominant familial spastic paraplegia (SPG) for linkage to four recently identified SPG loci on chromosomes 2q (1), 8q (2), 12q (3), and 19q (4). These families were previously shown to be unlinked to SPG loci on chromosomes 2p, 14q, and 15q. Two families demonstrated linkage to the new loci. One family (family 3) showed significant evidence for linkage to...

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PMID: 11354831
DOI: 10.1007/s100480000098

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