Article
The transcription factor E2F-1 is a downstream target of RB action.
Molecular and cellular biology - 1 Feb 1995
Qin X Q, Livingston D M, Ewen M, Sellers W R, Arany Z, Kaelin W G
Abstract excerpt
Reintroduction of RB into SAOS2 (RB-/-) cells causes a G1 arrest and characteristic cellular swelling. Coexpression of the cellular transcription factor E2F-1 could overcome these effects. The ability of E2F-1 to bind to RB was neither necessary nor sufficient for this effect, and S-phase entry was not accompanied by RB hyperphosphorylation under these conditions. Furthermore, E2F-1 could overcome the actions of...
Topics
- Base Sequence
- Binding Sites
- Bone Neoplasms
- Carrier Proteins
- Cell Cycle
- Cell Cycle Proteins
- Cell Line
- Chloramphenicol O-Acetyltransferase
- DNA Primers
- DNA-Binding Proteins
- E2F Transcription Factors