Article
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 1995
Sellers W R, Rodgers J W, Kaelin W G
Abstract excerpt
An intact T/E1A-binding domain (the pocket) is necessary, but not sufficient, for the retinoblastoma protein (RB) to bind to DNA-protein complexes containing E2F and for RB to induce a G1/S block. Indirect evidence suggests that the binding of RB to E2F may, in addition to inhibiting E2F transact...
Topics
- Animals
- Base Sequence
- Carrier Proteins
- Cell Cycle
- Cell Cycle Proteins
- Cells, Cultured
- DNA
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Promoter Regions, Genetic
- Protein Binding
- Protein Structure, Tertiary
- Recombinant Fusion Proteins