Article
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 1995
Sellers W R, Rodgers J W, Kaelin W G
Abstract excerpt
An intact T/E1A-binding domain (the pocket) is necessary, but not sufficient, for the retinoblastoma protein (RB) to bind to DNA-protein complexes containing E2F and for RB to induce a G1/S block. Indirect evidence suggests that the binding of RB to E2F may, in addition to inhibiting E2F transactivation function, generate a complex capable of functioning as a transrepressor. Here we show that a chimera in which...
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