Article
Somatic hypermutation and VH gene usage in hairy cell leukaemia.
British journal of haematology - 1 Jun 2006
Arons Evgeny, Sunshine Joel, Suntum Tara, Kreitman Robert J
Abstract excerpt
To examine the usage and mutational status of VH genes in hairy cell leukaemia (HCL), we analysed 24 immunoglobulin heavy chain (IgH) sequences expressed in 23 patients. None had premature stop codons. VH3-23 was the most common gene and a VH6 gene was observed for the first time in HCL. Although the mean mutation frequency was 6.1%, slightly higher than in previous HCL series, four patients had 99.6-100%...
Topics
- Base Sequence
- Gene Expression Regulation, Leukemic
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin Heavy Chain
- Germ-Line Mutation
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Leukemia, Hairy Cell
- Mutation
- Sequence Homology, Nucleic Acid
- Somatic Hypermutation, Immunoglobulin