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Article

Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia.

Haematologica - 1 May 2008

Forconi Francesco, Sozzi Elisa, Rossi Davide, Sahota Surinder S, Amato Teresa, Raspadori Donatella, Trentin Livio, Leoncini Lorenzo, Gaidano Gianluca, Lauria Francesco

Abstract excerpt

BACKGROUND: We previously reported ongoing mutational and isotype switch events in the immunoglobulin (Ig) heavy chain (H) locus in hairy cell leukemia. Those analyses raised questions on the incidence and type of selective influences occurring on the tumor B-cell receptor of hairy cell leukemia. DESIGN AND METHODS: To further investigate this issue, we examined the full IGH and kappa and lambda light chains...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

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Source

Identifiers

PMID: 18387977
DOI: 10.3324/haematol.12282

Genes

IGH
IGK
IGL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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