Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unusual deletions within the immunoglobulin heavy-chain locus in acute leukemias.

Blood - 1 Aug 1993

Dyer M J, Heward J M, Zani V J, Buccheri V, Catovsky D

Abstract excerpt

We have investigated the structure of the Ig heavy (IGH) chain locus in 309 cases of acute leukemia. Seventy-one cases of B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) were analyzed: in six cases deletion of joining (JH) segments in the presence of cytogenetically normal chromosome 14 was observed. Similar deletions were seen in 1 out of 8 cases of biphenotypic acute leukemia analyzed: this case...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Sequence Deletion
Share to Adolescent
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Aberrations

Share to Chromosome Disorders

Share to Genes, Immunoglobulin

Share to Restriction Mapping

Source

Identifiers

PMID: 8338950

Genes

IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unusual deletions within the immunoglobulin heavy-chain locus in acute leukemias.PMID 8338950Read ↗

Aberrant rearrangements within the immunoglobulin heavy chain locus in hairy cell leukemia.Semantic proximity Read ↗

Distinct ongoing Ig heavy chain rearrangement processes in childhood B- precursor acute lymphoblastic leukemiaSemantic proximity Read ↗

Utilization of Ig heavy chain variable, diversity, and joining gene segments in children with B-lineage acute lymphoblastic leukemia: implications for the mechanisms of VDJ recombination and for pathogenesisSemantic proximity Read ↗

BCL2 translocations in leukemias of mature B cellsSemantic proximity Read ↗

Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemiaSemantic proximity Read ↗

Immunoglobulin heavy chain gene VH-D junctional diversity at diagnosis in patients with acute lymphoblastic leukemia.Semantic proximity Read ↗

Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesisSemantic proximity Read ↗

Molecular diversity of precursor B acute lymphoblastic leukemias identified by the immunoglobulin heavy chain gene organization.Semantic proximity Read ↗

Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain diseaseSemantic proximity Read ↗

Precursor-B-ALL with D(H)-J(H) gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14.Semantic proximity Read ↗

Oncogene rearrangements in chronic B-cell leukemia.Semantic proximity Read ↗

Rapid Molecular Cloning of Rearrangements of the IGHJ Locus Using Long-Distance Inverse Polymerase Chain ReactionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.