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Article

Isotype switch and idiotype variation in hairy cell leukemia.

Leukemia - 1 Dec 1990

Heirman C, Vaeremans E, Carels D, Theunissen J, Van Camp B, Thielemans K

Abstract excerpt

Hairy cell leukemia (HCL) cells are B lymphocytes expressing monoclonal surface bound immunoglobulins, B cell specific antigens, and activation markers. Based on immunophenotyping analysis, HCL cells have been reported to express simultaneously multiple Ig heavy chain isotypes. This is in contrast with the majority of other B cell malignancies. To analyse the tumor cell Ig in more detail, we have prepared somatic...

Topics

Antibodies, Anti-Idiotypic
Blotting, Southern
Cell Membrane
Cytoplasm
Gene Expression Regulation
Gene Rearrangement
Humans
Hybridomas
Immunoglobulin Idiotypes
Immunoglobulin Isotypes
Leukemia, Hairy Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Monocytes

Mutation

Source

Identifiers

PMID: 2243508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2243508-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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