Lack of allelic exclusion by secondary rearrangements of tumour B-cell receptor light chains in hairy cell leukaemia.

doi:10.1002/hon.952

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Article

Lack of allelic exclusion by secondary rearrangements of tumour B-cell receptor light chains in hairy cell leukaemia.

Hematological oncology - 1 Mar 2011

Sozzi Elisa, Amato Teresa, Sahota Surinder S, Nuti Sandra, Raspadori Donatella, Sicuranza Anna, Cencini Emanuele, Tosi Piero, Lauria Francesco, Forconi Francesco

Abstract excerpt

Analyses of the tumour immunoglobulin (Ig) gene (IG) heavy (H) and light chains show heterogeneity of mutational status, but reveal common features of ongoing IGH isotype-switching with multiple IGH isotype expression and preference of IG lambda (IGL) light chain with selective use of IGLJ3. Phenotypic and immunogenetic analyses were performed in a series of 105 HCL patients to estimate prevalence of multiple IG...

Topics

Alleles
Gene Rearrangement, B-Lymphocyte, Light Chain
Homeodomain Proteins
Humans
Immunoglobulin Heavy Chains
Leukemia, Hairy Cell
Receptors, Antigen, B-Cell

Source

Open in PubMed

Identifiers

PMID: 20658474
DOI: 10.1002/hon.952

Genes

IGL
IGK
IGH
BCR
RAG1

Provenance

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