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Article

Evidence of canonical somatic hypermutation in hairy cell leukemia

2 Mar 2011

Abstract excerpt

To compare hairy cell leukemia (HCL) with chronic lymphocytic leukemia (CLL) and normal B cells with respect to their B-cell receptors, somatic hypermutation (SHM) features in HCL were examined in a series of 130 immunoglobulin gene heavy chain rearrangements, including 102 from 100 classic (HCLc) and 28 from 26 variant (HCLv) patients. The frequency of unmutated rearrangements in HCLc was much lower than that in...

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PMID: 21368287
DOI: 10.1182/blood-2010-11-316737

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