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Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch.

Blood - 15 Nov 2004

Forconi Francesco, Sahota Surinder S, Raspadori Donatella, Ippoliti Micaela, Babbage Gavin, Lauria Francesco, Stevenson Freda K

Abstract excerpt

Hairy cell leukemia (HCL) commonly expresses multiple immunoglobulin isotypes, a feature rare in other B-cell malignancies or in normal B cells. In HCL, there is no phenotypic evidence for subpopulations, and single cells from one previous case contained transcripts for several isotypes. This raises the questions of the differentiation status of the cell of origin and of posttransformation events. We have...

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PMID: 15284115
DOI: 10.1182/blood-2004-03-0950

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