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Article

The targeting of somatic hypermutation.

Seminars in immunology - 1 Jun 1996

Jolly C J, Wagner S D, Rada C, Klix N, Milstein C, Neuberger M S

Abstract excerpt

Somatic hypermutation does not occur randomly within immunoglobulin V genes but, rather, is preferentially targeted to certain nucleotide positions (hot spots) and away from others (cold spots). Cold spots often coincide with residues essential for V gene folding. Hotspots, which appear to be strategically located to favour affinity maturation, are most frequently located in the CDRs (particularly CDR1) though...

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Identifiers

PMID: 8738915
DOI: 10.1006/smim.1996.0020

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