The targeting of somatic hypermutation.

doi:10.1006/smim.1996.0020

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Article

The targeting of somatic hypermutation.

Seminars in immunology - 1 Jun 1996

Jolly C J, Wagner S D, Rada C, Klix N, Milstein C, Neuberger M S

Abstract excerpt

Somatic hypermutation does not occur randomly within immunoglobulin V genes but, rather, is preferentially targeted to certain nucleotide positions (hot spots) and away from others (cold spots). Cold spots often coincide with residues essential for V gene folding. Hotspots, which appear to be str...

Topics

Animals
Codon
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region
Mice
Mutation

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