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Article

The role of T cell receptor beta chain genes in susceptibility to rheumatoid arthritis.

Arthritis and rheumatism - 1 Jan 1995

McDermott M, Kastner D L, Holloman J D, Schmidt-Wolf G, Lundberg A S, Sinha A A, Hsu C, Cashin P, Molloy M G, Mulcahy B

Abstract excerpt

OBJECTIVE: To evaluate the role of the T cell receptor beta chain locus (TCRB) in genetic susceptibility to rheumatoid arthritis (RA). METHODS: Twenty-eight multiplex RA families were recruited from 3 rheumatology outpatient departments. All members were genotyped for a highly informative microsatellite (V beta 6.7), a V beta 12.2 SSCP marker, and a biallelic C beta restriction fragment length polymorphism. Data...

Topics

Adolescent
Adult
Alleles
Arthritis, Rheumatoid
Disease Susceptibility
Female
Genetic Markers
Genotype
HLA-DR Antigens
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 7818578
DOI: 10.1002/art.1780380114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7818578-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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