Article
HLA class II and T-cell receptor beta chain polymorphisms in Belgian patients with rheumatoid arthritis: no evidence for disease association with the TCRBC2, TCRBV8 and TCRBV11 polymorphisms.
Annals of the rheumatic diseases - 1 Sept 1994
Vandevyver C, Gu X X, Geusens P, Spaepen M, Philippaerts L, Cassiman J J, Raus J
Abstract excerpt
OBJECTIVES: To investigate whether T-cell receptor (TCR) beta chain germline alleles, either alone or in combination with a particular HLA-genotype, are associated with rheumatoid arthritis (RA). METHODS: Three restriction fragment length polymorphisms (RFLPs), detected with TCR constant (TCRBC2)...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Arthritis, Rheumatoid
- Base Sequence
- DNA Probes
- Female
- HLA-DR Antigens
- HLA-DR4 Antigen
- HLA-DRB1 Chains
- Humans
- Immunoglobulin Constant Regions
- Immunoglobulin Variable Region