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Article

Analysis of antibody markers, DRB1, DRB5, DQA1 and DQB1 genes and modeling of DR2 molecules in DR2-positive patients with insulin-dependent diabetes mellitus.

Tissue antigens - 1 Aug 1994

Sanjeevi C B, Lybrand T P, Landin-Olsson M, Kockum I, Dahlquist G, Hagopian W A, Palmer J P, Lernmark A

Abstract excerpt

HLA-DR2 is negatively associated with insulin-dependent diabetes mellitus (IDDM). The aim of the present study was to analyze DR2-positive patients among 425 consecutively diagnosed unrelated Swedish children with IDDM and in 367 matched controls. HLA-DRB, -DQA and -DQB were determined by Taq I restriction fragment length polymorphism analysis. Amplification by polymerase chain reaction (PCR) and hybridization...

Topics

Alleles
Animals
Antibodies, Monoclonal
Base Sequence
Cricetinae
Diabetes Mellitus, Type 1
Disease Susceptibility
Genes, MHC Class II
Genetic Predisposition to Disease
HLA-DQ Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ alpha-Chains

HLA-DQ beta-Chains

HLA-DR Antigens

HLA-DR2 Antigen

HLA-DRB1 Chains

HLA-DRB5 Chains

Haplotypes

Humans

Source

Identifiers

PMID: 7817375
DOI: 10.1111/j.1399-0039.1994.tb02366.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7817375-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analysis of antibody markers, DRB1, DRB5, DQA1 and DQB1 genes and modeling of DR2 molecules in DR2-positive patients with insulin-dependent diabetes mellitus.PMID 7817375Read ↗

Multi-locus analysis of HLA class II genes in DR2-positive IDDM haplotypes in Finland. The "Childhood Diabetes in Finland" (DiMe) Study Group.Semantic proximity Read ↗

HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population.Semantic proximity Read ↗

DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.Semantic proximity Read ↗

HLA-DRB1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus.Semantic proximity Read ↗

Susceptible and protective human leukocyte antigen class II alleles and haplotypes in bahraini type 2 (non-insulin-dependent) diabetes mellitus patients.Semantic proximity Read ↗

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.Semantic proximity Read ↗

HLA-DR and -DQ associations with insulin-dependent diabetes mellitus in a population of Turkey.Semantic proximity Read ↗

Association of particular HLA class II alleles, haplotypes and genotypes with susceptibility to IDDM in the Belgian population.Semantic proximity Read ↗

Analysis of critical residues of HLA-DQ6 molecules in insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Effects of the second HLA-DQ haplotype on the association with childhood insulin-dependent diabetes mellitus.Semantic proximity Read ↗

The HLA-DRB, -DQB polymorphism and anti-insulin antibody response in Slovenian patients with type 1 diabetes.Semantic proximity Read ↗

DQA1 and DQB1 heterodimers in insulin-dependent diabetes mellitus: a genetic-epidemiological study in Finland. DiMe Study Group.Semantic proximity Read ↗

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