The HLA-DRB, -DQB polymorphism and anti-insulin antibody response in Slovenian patients with type 1 diabetes.

doi:10.1046/j.1365-2370.2003.00395.x

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Article

The HLA-DRB, -DQB polymorphism and anti-insulin antibody response in Slovenian patients with type 1 diabetes.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Jun 2003

Battelino T, Ursic-Bratina N, Dolzan V, Stopar-Obreza M, Pozzilli P, Krzisnik C, Vidan-Jeras B

Abstract excerpt

A combination of specific HLA class II antigens and the presence of type 1 diabetes (T1D)-related antibodies has a high positive predictive value for T1D but low sensitivity. The aim of the present study was to determine the frequencies of HLA-DRB-DQB deduced haplotypes associated with susceptibility and protection in Slovenian patients with established T1D, to evaluate the relationship between the...

Topics

Adolescent
Adult
Antibodies
Autoantibodies
Case-Control Studies
Child
Child, Preschool
Diabetes Mellitus, Type 1
Gene Frequency
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutamate Decarboxylase

HLA-DQ Antigens

HLA-DQ beta-Chains

HLA-DR Antigens

HLA-DRB1 Chains

Humans

Insulin

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 12787001
DOI: 10.1046/j.1365-2370.2003.00395.x

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