Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.

The Journal of biological chemistry - 6 Jan 1995

Southwick F S

Abstract excerpt

Nonmuscle cell motility requires marked changes in the consistency and shape of the peripheral cytoplasm. These changes are regulated by a gel-sol transformation of the actin filament network, and actin filament-severing proteins are responsible for network solation. Macrophage Cap G, unlike all other proteins in the gelsolin family, caps but does not sever actin filaments. Two amino acid stretches in Cap G...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Macrophages
Share to Molecular Sequence Data
Share to Actins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amino Acid Sequence

Share to Mutation

Share to Nuclear Proteins

Share to Sequence Homology, Amino Acid

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 7814409
DOI: 10.1074/jbc.270.1.45

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.PMID 7814409Read ↗

Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF.Semantic proximity Read ↗

Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin.Semantic proximity Read ↗

Complex eukaryotic-like actin regulation systems from Asgard archaeaSemantic proximity Read ↗

Macrophage capping protein CapG is a putative oncogene involved in migration and invasiveness in ovarian carcinoma.Semantic proximity Read ↗

Chimeric and truncated gCap39 elucidate the requirements for actin filament severing and end capping by the gelsolin family of proteins.Semantic proximity Read ↗

Yersinia effector protein (YopO)-mediated phosphorylation of host gelsolin causes calcium-independent activation leading to disruption of actin dynamics.Semantic proximity Read ↗

The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins.Semantic proximity Read ↗

Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein.Semantic proximity Read ↗

Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin.Semantic proximity Read ↗

The actin-severing activity of cofilin is exerted by the interplay of three distinct sites on cofilin and essential for cell viability.Semantic proximity Read ↗

Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.Semantic proximity Read ↗

Structure/function analysis of the interaction of phosphatidylinositol 4,5-bisphosphate with actin-capping protein: implications for how capping protein binds the actin filament.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.