Article
Yersinia effector protein (YopO)-mediated phosphorylation of host gelsolin causes calcium-independent activation leading to disruption of actin dynamics.
The Journal of biological chemistry - 12 May 2017
Singaravelu Pavithra, Lee Wei Lin, Wee Sheena, Ghoshdastider Umesh, Ding Ke, Gunaratne Jayantha, Grimes Jonathan M, Swaminathan Kunchithapadam, Robinson Robert C
Abstract excerpt
Pathogenic Yersinia bacteria cause a range of human diseases. To modulate and evade host immune systems, these yersiniae inject effector proteins into host macrophages. One such protein, the serine/threonine kinase YopO (YpkA in Yersinia pestis), uses monomeric actin as bait to recruit and phosphorylate host actin polymerization-regulating proteins, including the actin-severing protein gelsolin, to disrupt actin...
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