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Article

Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2009

Nag Shalini, Ma Qing, Wang Hui, Chumnarnsilpa Sakesit, Lee Wei Lin, Larsson Mårten, Kannan Balakrishnan, Hernandez-Valladares Maria, Burtnick Leslie D, Robinson Robert C

Abstract excerpt

Gelsolin consists of six homologous domains (G1-G6), each containing a conserved Ca-binding site. Occupation of a subset of these sites enables gelsolin to sever and cap actin filaments in a Ca-dependent manner. Here, we present the structures of Ca-free human gelsolin and of Ca-bound human G1-G3 in a complex with actin. These structures closely resemble those determined previously for equine gelsolin. However,...

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Identifiers

PMID: 19666512
DOI: 10.1073/pnas.0812374106
PMCID: PMC2720848

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Source receipt: pubmed, retrieved 7 Sept 2026.

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