Article
Macrophage capping protein CapG is a putative oncogene involved in migration and invasiveness in ovarian carcinoma.
BioMed research international - 1 Jan 2014
Glaser J, Neumann M H D, Mei Qi, Betz B, Seier N, Beyer I, Fehm T, Neubauer H, Niederacher D, Fleisch M C
Abstract excerpt
The actin binding protein CapG modulates cell motility by interacting with the cytoskeleton. CapG is associated with tumor progression in different nongynecologic tumor entities and overexpression in breast cancer cell lines correlates with a more invasive phenotype in vitro. Here, we report a significant CapG overexpression in 18/47 (38%) of ovarian carcinomas (OC) analyzed by qRealTime-PCR analyses. Functional...
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