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Article

Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF.

The EMBO journal - 21 Jul 2004

Burtnick Leslie D, Urosev Dunja, Irobi Edward, Narayan Kartik, Robinson Robert C

Abstract excerpt

The actin filament-severing functionality of gelsolin resides in its N-terminal three domains (G1-G3). We have determined the structure of this fragment in complex with an actin monomer. The structure reveals the dramatic domain rearrangements that activate G1-G3, which include the replacement of interdomain interactions observed in the inactive, calcium-free protein by new contacts to actin, and by a novel G2-G3...

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Identifiers

PMID: 15215896
DOI: 10.1038/sj.emboj.7600280
PMCID: PMC514944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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