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Article

Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. Analysis of mutant cytoplasmic receptor domains.

The Journal of biological chemistry - 6 Jan 1995

Körner C, Nürnberg B, Uhde M, Braulke T

Abstract excerpt

The binding of insulin-like growth factor II (IGF II) to the mannose 6-phosphate (M6P)/IGF II receptor has previously been reported to induce the activation of trimeric G(i)2 proteins by functional coupling to a 14-amino acid region within the cytoplasmic receptor domain (Nishimoto, I., Murayama, Y., Katada, T., Ui, M., and Ogata, E. (1989) J. Biol. Chem. 264, 14029-14038). In the present study, we examined...

Topics

Adenosine Diphosphate Ribose
Animals
Catalysis
Cytoplasm
GTP Phosphohydrolases
GTP-Binding Proteins
Humans
Insulin-Like Growth Factor II
L Cells
Mannosephosphates
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pertussis Toxin

Phospholipids

Receptor, IGF Type 2

Virulence Factors, Bordetella

Source

Identifiers

PMID: 7814388
DOI: 10.1074/jbc.270.1.287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7814388-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. Analysis of mutant cytoplasmic receptor domains.PMID 7814388Read ↗

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