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Article

The mannose 6-phosphate-binding sites of M6P/IGF2R determine its capacity to suppress matrix invasion by squamous cell carcinoma cells.

The Biochemical journal - 1 Apr 2013

Probst Olivia C, Karayel Evren, Schida Nicole, Nimmerfall Elisabeth, Hehenberger Elisabeth, Puxbaum Verena, Mach Lukas

Abstract excerpt

The M6P (mannose 6-phosphate)/IGF2R (insulin-like growth factor II receptor) interacts with a variety of factors that impinge on tumour invasion and metastasis. It has been shown that expression of wild-type M6P/IGF2R reduces the tumorigenic and invasive properties of receptor-deficient SCC-VII squamous cell carcinoma cells. We have now used mutant forms of M6P/IGF2R to assess the relevance of the different...

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Share to Carcinoma, Squamous Cell
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Extracellular Matrix

Share to Insulin-Like Growth Factor II

Share to Neoplasm Invasiveness

Share to Neoplasm Proteins

Share to Protein Structure, Tertiary

Share to Receptor, IGF Type 2

Source

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Identifiers

PMID: 23347038
DOI: 10.1042/BJ20121422
PMCID: PMC3632087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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