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Article

Regulation of biological functions by an insulin receptor monoclonal antibody in insulin receptor beta-subunit mutants.

Biochemistry - 14 Jan 1992

Sung C K, Han X L, Brunetti A, Maddux B, Yamamoto-Honda R, Goldfine I D

Abstract excerpt

We investigated the effects of MA-5, a human-specific monoclonal antibody to the insulin receptor alpha-subunit, on transmembrane signaling in cell lines transfected with and expressing both normal human insulin receptors and receptors mutated in their beta-subunit tyrosine kinase domains. In cell lines expressing normal human insulin receptors, MA-5 stimulated three biological functions: aminoisobutyric acid...

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PMID: 1731870
DOI: 10.1021/bi00116a025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Regulation of biological functions by an insulin receptor monoclonal antibody in insulin receptor beta-subunit mutants.PMID 1731870Read ↗

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