Article
Regulation of biological functions by an insulin receptor monoclonal antibody in insulin receptor beta-subunit mutants.
Biochemistry - 14 Jan 1992
Sung C K, Han X L, Brunetti A, Maddux B, Yamamoto-Honda R, Goldfine I D
Abstract excerpt
We investigated the effects of MA-5, a human-specific monoclonal antibody to the insulin receptor alpha-subunit, on transmembrane signaling in cell lines transfected with and expressing both normal human insulin receptors and receptors mutated in their beta-subunit tyrosine kinase domains. In cell lines expressing normal human insulin receptors, MA-5 stimulated three biological functions: aminoisobutyric acid...
Topics
- Aminoisobutyric Acids
- Animals
- Antibodies, Monoclonal
- Binding Sites
- Cell Line
- Cricetinae
- Cricetulus
- Enzyme Activation
- Female
- Humans
- Mutation
- Phosphorylation