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Article

Combined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis.

PloS one - 1 Jan 2018

Gerasimou Petroula, Nicolaidou Vicky, Skordis Nicos, Picolos Michalis, Monos Demetrios, Costeas Paul A

Abstract excerpt

The contribution of specific HLA Class II alleles in type 1 diabetes is determined by polymorphic amino acid epitopes that direct antigen binding therefore, along with conventional allele frequency analysis, epitope analysis can provide important insights into disease susceptibility. We analyzed the highly heterogeneous Cypriot population for the HLA class II loci of T1DM patients and controls and we report for...

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Identifiers

PMID: 29494662
DOI: 10.1371/journal.pone.0193684
PMCID: PMC5832312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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