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Article

HLA-DQ6-mediated protection in IDDM.

Human immunology - 1 Feb 2000

Sanjeevi C B

Abstract excerpt

Insulin-dependent diabetes mellitus is positively associated with DQ8, DQ2, and DQ6 (DQB1*0604), and negatively associated with DQ6 (DQB1*0602), DQ6 (DQB1*0603), and DQ7 in Swedish caucasians. The protection conferred by DQ6 (DQB1*0602) is stronger in younger individuals and there is decrease in the effect of protection with increasing age. Three-dimensional modeling of the susceptible DQ6 (DQB1*0604) and...

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Source

Identifiers

PMID: 10717807
DOI: 10.1016/s0198-8859(99)00146-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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HLA-DQ6-mediated protection in IDDM.PMID 10717807Read ↗

Analysis of critical residues of HLA-DQ6 molecules in insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Molecular modelling of HLA-DQ suggests a mechanism of resistance in type 1 diabetes.Semantic proximity Read ↗

Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles.Semantic proximity Read ↗

Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM. Members of the Swedish Childhood Diabetes Study.Semantic proximity Read ↗

HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection.Semantic proximity Read ↗

Insulin dependent diabetes mellitus susceptibility or protection may be determined by certain HLA-DQ molecules.Semantic proximity Read ↗

Polymorphic structural features of modelled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM.Semantic proximity Read ↗

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

The combination of several polymorphic amino acid residues in the DQalpha and DQbeta chains forms a domain structure pattern and is associated with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.Semantic proximity Read ↗

Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 DiabetesSemantic proximity Read ↗

HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.Semantic proximity Read ↗

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