Article
Adhesion, growth, and matrix production by osteoblasts on collagen substrata.
Calcified tissue international - 1 Sept 1992
Masi L, Franchi A, Santucci M, Danielli D, Arganini L, Giannone V, Formigli L, Benvenuti S, Tanini A, Beghè F
Abstract excerpt
A number of studies have demonstrated the pivotal role of collagen molecules in modulating cell growth and differentiation. In order to analyze the direct effects of collagen type I on the osteoblastic phenotype, we have devised an in vitro culture system for studying the interactions between bovine collagen type I and Saos-2 cells, a human osteoblastic cell line. Saos-2 cells were cultured both on top of...
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