Glycogen synthase kinase 3 regulates cell fate in Dictyostelium.

doi:10.1016/0092-8674(95)90458-1

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Article

Glycogen synthase kinase 3 regulates cell fate in Dictyostelium.

Cell - 13 Jan 1995

Harwood A J, Plyte S E, Woodgett J, Strutt H, Kay R R

Abstract excerpt

Extracellular cyclic AMP (cAMP) induces the formation of prespore cells in Dictyostelium but inhibits stalk cell formation. We have cloned gskA, which encodes the Dictyostelium homolog of glycogen synthase kinase 3 (GSK-3), and discovered that it is required for both cAMP effects. Disruption of g...

Topics

Amino Acid Sequence
Animals
Base Sequence
Calcium-Calmodulin-Dependent Protein Kinases
Cell Differentiation
Cyclic AMP
Dictyostelium
Extracellular Matrix Proteins
Fungal Proteins
Genes, Fungal
Glycogen Synthase Kinase 3
Glycogen Synthase Kinases
Molecular Sequence Data
Mutation
Phenotype
Protozoan Proteins
Spores, Fungal

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Identifiers

PMID: 7813009
DOI: 10.1016/0092-8674(95)90458-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7813009-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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