Article
gyrA mutations associated with fluoroquinolone resistance in eight species of Enterobacteriaceae.
Antimicrobial agents and chemotherapy - 1 Oct 1998
Weigel L M, Steward C D, Tenover F C
Abstract excerpt
Fluoroquinolone resistance (FQ-R) in clinical isolates of Enterobacteriaceae species has been reported with increasing frequency in recent years. Two mechanisms of FQ-R have been identified in gram-negative organisms: mutations in DNA gyrase and reduced intracellular drug accumulation. A single point mutation in gyrA has been shown to reduce susceptibility to fluoroquinolones. To determine the extent of gyrA...
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