Article
gyrA mutations associated with fluoroquinolone resistance in eight species of Enterobacteriaceae.
Antimicrobial agents and chemotherapy - 1 Oct 1998
Weigel L M, Steward C D, Tenover F C
Abstract excerpt
Fluoroquinolone resistance (FQ-R) in clinical isolates of Enterobacteriaceae species has been reported with increasing frequency in recent years. Two mechanisms of FQ-R have been identified in gram-negative organisms: mutations in DNA gyrase and reduced intracellular drug accumulation. A single point mutation in gyrA has been shown to reduce susceptibility to fluoroquinolones. To determine the extent of gyrA...
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- DNA Gyrase
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Enterobacteriaceae
- Fluoroquinolones
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction