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Article

Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.

Antimicrobial agents and chemotherapy - 1 Oct 1994

Vila J, Ruiz J, Marco F, Barcelo A, Goñi P, Giralt E, Jimenez de Anta T

Abstract excerpt

The mutations in the quinolone resistance-determining region of the gyrA and gyrB genes from 27 clinical isolates of Escherichia coli with a range of MICs of ciprofloxacin from 0.007 to 128 micrograms/ml and of nalidixic acid from 2 to > 2,000 micrograms/ml were determined by DNA sequencing. All...

Topics

Amino Acid Sequence
Base Sequence
Ciprofloxacin
DNA Gyrase
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Escherichia coli
Microbial Sensitivity Tests
Molecular Sequence Data
Mutation

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Identifiers

PMID: 7840592
DOI: 10.1128/AAC.38.10.2477
PMCID: PMC284767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7840592-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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