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Article

Development of fluoroquinolone resistance in Enterococcus faecalis and role of mutations in the DNA gyrase gyrA gene.

Antimicrobial agents and chemotherapy - 1 Nov 1996

Tankovic J, Mahjoubi F, Courvalin P, Duval J, Leclerco R

Abstract excerpt

We have analyzed the development of fluoroquinolone resistance between 1986 and 1993 among clinical isolates of Enterococcus faecalis from a French hospital. One hundred randomly selected isolates per year were screened for resistance to ciprofloxacin (MIC > 2 micrograms/ml) and for high-level resistance to gentamicin (MIC > 1,000 micrograms/ml). The percentages of ciprofloxacin-resistant strains for these years...

Topics

Anti-Infective Agents
DNA Topoisomerases, Type II
DNA, Bacterial
Electrophoresis, Polyacrylamide Gel
Enterococcus faecalis
Fluoroquinolones
France
Gram-Positive Bacterial Infections
Microbial Sensitivity Tests
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 8913464
DOI: 10.1128/AAC.40.11.2558
PMCID: PMC163575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8913464-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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