Article
Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.
Antimicrobial agents and chemotherapy - 1 Jul 1995
Reyna F, Huesca M, González V, Fuchs L Y
Abstract excerpt
Spontaneous quinolone-resistant mutants obtained from Salmonella typhimurium Su694 were screened for mutations by direct DNA sequencing of an amplified PCR gyrA fragment. Substitutions Ser-83-->Phe (Ser83Phe), Ser83Tyr, Asp87Tyr, and Asp87Asn and double mutation Ala67Pro-Gly81Ser, which resulted...
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- DNA Gyrase
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Microbial
- Fluoroquinolones
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Salmonella typhimurium
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid