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Article

Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.

Antimicrobial agents and chemotherapy - 1 Jul 1995

Reyna F, Huesca M, González V, Fuchs L Y

Abstract excerpt

Spontaneous quinolone-resistant mutants obtained from Salmonella typhimurium Su694 were screened for mutations by direct DNA sequencing of an amplified PCR gyrA fragment. Substitutions Ser-83-->Phe (Ser83Phe), Ser83Tyr, Asp87Tyr, and Asp87Asn and double mutation Ala67Pro-Gly81Ser, which resulted in decreased sensitivities to ciprofloxacin, enoxacin, pefloxacin, norfloxacin, ofloxacin, and nalidixic acid, were...

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Identifiers

PMID: 7492118
DOI: 10.1128/AAC.39.7.1621
PMCID: PMC162795

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Source receipt: pubmed, retrieved 7 Sept 2026.

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