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DNA sequence analysis of DNA gyrase and DNA topoisomerase IV quinolone resistance-determining regions of Salmonella enterica serovar Typhi and serovar Paratyphi A.

Antimicrobial agents and chemotherapy - 1 Oct 2002

Hirose Kenji, Hashimoto Ai, Tamura Kazumichi, Kawamura Yoshiaki, Ezaki Takayuki, Sagara Hiroko, Watanabe Haruo

Abstract excerpt

The mutations that are responsible for fluoroquinolone resistance in the gyrA, gyrB, parC, and parE genes of Salmonella enterica serovar Typhi and serovar Paratyphi A were investigated. The sequences of the quinolone resistance-determining region of the gyrA gene in clinical isolates which showed decreased susceptibilities to fluoroquinolones had a single mutation at either the Ser-83 or the Asp-87 codon, and no...

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Identifiers

PMID: 12234852
DOI: 10.1128/AAC.46.10.3249-3252.2002
PMCID: PMC128770

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Source receipt: pubmed, retrieved 7 Sept 2026.

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