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Article

GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.

Antimicrobial agents and chemotherapy - 1 Apr 1996

Stieger M, Angehrn P, Wohlgensinger B, Gmünder H

Abstract excerpt

The sequence of the gyrase B subunit gene from Staphylococcus aureus strains resistant to the gyrase B subunit inhibitors cyclothialidine, coumermycin, and novobiocin has been determined. The residues altered in the resistant gyrase B subunits map to the ATP-binding region, suggesting that the drugs inhibit ATP binding and hydrolysis. The pattern of cross-resistances indicates that the detailed binding mode of...

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Identifiers

PMID: 8849232
DOI: 10.1128/AAC.40.4.1060
PMCID: PMC163264

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