Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition.

Journal of molecular biology - 13 Apr 2001

Heddle J G, Blance S J, Zamble D B, Hollfelder F, Miller D A, Wentzell L M, Walsh C T, Maxwell A

Abstract excerpt

Microcin B17 is a 3.1-kDa bactericidal peptide; the putative target of this antibiotic is DNA gyrase. Microcin B17 has no detectable effect on gyrase-catalysed DNA supercoiling or relaxation activities in vitro and is unable to stabilise DNA cleavage in the absence of nucleotides. However, in the presence of ATP, or the non-hydrolysable analogue 5'-adenylyl beta,gamma-imidodiphosphate, microcin B17 stabilises a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriocins
Share to Ciprofloxacin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Coumarins

Share to Cytotoxins

Share to DNA, Superhelical

Share to DNA Topoisomerases, Type II

Share to Nucleic Acid Synthesis Inhibitors

Share to Topoisomerase II Inhibitors

Source

Identifiers

PMID: 11292337
DOI: 10.1006/jmbi.2001.4562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition.PMID 11292337Read ↗

The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyrase.Semantic proximity Read ↗

Construction and characterization of mutations at codon 751 of the Escherichia coli gyrB gene that confer resistance to the antimicrobial peptide microcin B17 and alter the activity of DNA gyrase.Semantic proximity Read ↗

A 2.8 Å Structure of Zoliflodacin in a DNA Cleavage Complex with Staphylococcus aureus DNA GyraseSemantic proximity Read ↗

Bacterial topoisomerase I as a target for discovery of antibacterial compounds.Semantic proximity Read ↗

Structure of Microcin B-Like Compounds Produced by Pseudomonas syringae and Species Specificity of Their Antibacterial ActionSemantic proximity Read ↗

Drug Interactions with <i>Bacillus anthracis</i> Topoisomerase IV: Biochemical Basis for Quinolone Action and ResistanceSemantic proximity Read ↗

Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.Semantic proximity Read ↗

Molecular characterization of pmbA, an Escherichia coli chromosomal gene required for the production of the antibiotic peptide MccB17.Semantic proximity Read ↗

Mutations of bacterial RNA polymerase leading to resistance to microcin j25.Semantic proximity Read ↗

Quinolones: action and resistance updated.Semantic proximity Read ↗

Inhibition of type IA topoisomerase by a monoclonal antibody through perturbation of DNA cleavage-religation equilibrium.Semantic proximity Read ↗

gyrB-225, a mutation of DNA gyrase that compensates for topoisomerase I deficiency: investigation of its low activity and quinolone hypersensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.